ABSTRACT
Objective To study the clinical efficacy of Wenweinjiangni granule combined with allantoin aluminum on patients with peptic ulcer and the changes of serum gastrin,transforming growth factor-α(TGF-α)and interleukin-8(IL-8)to explore the best treatment for patients with peptic ulcer.Methods 86 patients with peptic ulcer admitted in our hospital from July 2014 to July 2015 were selected as subjects of this study.The control group was treated with allantoin aluminum,and the observation group was treated with Wenweijiangni granule combined with allantoin.The serum levels of Gas,TGF-α,IL-8,adverse reaction and therapeutic effect were observed in the two groups.Results After treatment,the levels of Gas and IL-8 in the observation group were significantly lower than those in the control group [(68.96±21.26)pg/mL vs.(82.75±24.08)pg/mL(6.93±2.31)μg/L vs.(5.06±2.07)μg/L,(11.86±2.10)μg/L vs.(14.97±2.76)μg/L](P<0.05).The total incidence of side effects in the observation group was less than that in the control group(6.97％vs.23.25％)(P<0.05).The total effective rate of the observation group was better than that of the control group(95.34％vs.76.74％)(P<0.05).Conclusion The combination of Wenweijiangni granule and allantoin aluminum can improve the ulcer surface of patients with peptic ulcer,improve Gas,TGF-α and IL-8,which is more effective and more effective than aluminum allantoin alone.
ABSTRACT
Objective To evaluate the therapeutic effects of titanium clips occlusion for the defects and complications caused by endoscopic mucosal resection(EMR).Methods Totally 62 patients with protuberant lesions in the esophagus or gastrointestinal tract(≤15 mm in diameter) were treated by EMR in our hospital.During the operation,69 lesions were cut and the surgical defects were clipped using titanium clips.The intra-and post-operative complications of the patients were reviewed.Six weeks after the treatment,the patients received re-examination by endoscopy to observe the healing of the mucosal defects.Results The 69 lesions in the 62 cases were resected completely.At each defect,1-3 titanium clips were used,no perforation or hemorrhage occurred in the patients.Endoscopy performed in 6 weeks showed that all the defects were healed without ulcer,stenosis or recurrence.The titanium clips dropped 65 of the defected mucosa.Conclusion Titanium clips is effective and safe for defects caused by endoscopic mucosal resection.